ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Peptide Autacoids: Angiotensins And Kinins
Dr. A. Tuncay DEMİRYÜREK,a Dr. Ali Fuad KARAa
aFarmakoloji AD, Gaziantep Üniversitesi Tıp Fakültesi, GAZİANTEP
The objective of this review is to provide information about the biochemistry and physiology of the renin-angiotensin and kallikrein-kininogen-kinin systems, and summarize the pharmacology of drugs that affect these systems. Angiotensin II increases total peripheral resistance and thereby contributes to the short-term regulation of arterial blood pressure. Angiotensin II also changes renal function by inhibiting renal excretion of sodium and water and plays an important role in long-term regulation of arterial blood pressure. ACE inhibitors inhibit the conversion of the relatively inactive angiotensin I to the active angiotensin II. ACE inhibitors are widely used for patients with high-renin hypertension, patients with essential hypertension who have normal levels of plasma renin activity, congestive heart failure, myocardial infarction and diabetic nephropathy. Angiotensin II receptor blockers bind to the AT1 receptors and selectively inhibit most of the biological effects of angiotensin II. Vasopeptidase inhibitors are able to block both ACE and neutral endopeptidase. Chymase is a chymotrypsin-like serine protease secreted from mast cells and an important action of this enzyme is the ACE-independent conversion of angiotensin I to angiotensin II. Therefore, chymase inhibitors may also have a place in the treatment of vascular injury associated with mast cell degranulation.Keywords: Angiotensins, kinins, enzyme inhibitors, receptor antagonistsTurkiye Klinikleri J Int Med Sci 2005, 1(1):10-33
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