ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Basic Concepts Related With The Sensation Of Pain: Neurophysiological Mechanisms, Endogenous Opioid Peptides And Opioidergic Receptors
Dr. Aytül ÖNALa
aFarmakoloji AD, Ege Üniversitesi Tıp Fakültesi, İZMİR
Pain, defined as an unpleasant sensory and emotional experience associated with actual or potantial tissue damage is a symptom of many clinical disorders and treated by two main classes of drugs, which are opioids and non-streoidal antiinflammatory agents. Activity in the nociceptor and nociceptive pathways and other neurophysiological processes induced by a noxious stimulus is called nociception. Pain is state of perception within nociception and a way of affectivity which is altered with respect to the individual and condition in which it is found. Endogenous opioid peptides and opioid receptors are known to be important in modulating pain transmission Opioids exert their therapeutic effects by mimicking the action of endogenous opioid peptides at opioid receptors. This chapter will provide the background necessary to understand the mechanisms of pain transmission and its control based on the underlying anatomical organization and physiological responses. Also, the molecular characterization and pharmacological and functional properties of the opioid receptors will be summarized and the endogenous opioid system will be discussed with a focus on the receptors.Keywords: Pain, nociception, opioid peptid, opioid receptorTurkiye Klinikleri J Int Med Sci 2005, 1(9):1-14
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