ISSN: 1305-385X
Hakkında: Özel sayılar şeklinde yayınlanır.
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Nonsteroidal Antiinflammatory Drugs
Dr. G. Mehtap ÇINARa
aFarmakoloji AD, Ege Üniversitesi Tıp Fakültesi, İZMİR
Nonsteroidal antiinflammatory drugs are among the most widely used of all therapeutic agents. This drugs have antipyretic, analgesic and antiinflammatory effects. Particularly, it is used in arthritis, osteoarthritis and other rheumatic diseases a long time. Most currently nonsteroidal antiinflammatory drugs inhibit both cyclooxygenase-1 (COX-1; consti-tutive) and cyclooxygenase-2 (COX-2; induced in settings of inflamma-tion) activities. The inhibition of COX-2 is thought to mediate the anti-pyretic, analgesic and antiinflammatory action of nonsteroidal antiin-flammatory drugs. The simultaneous inhibition of COX-1 result in unwanted side effects as gastric ulcer. Shared therapeutic activities and side effects of nonsteroidal antiinflammatory drugs and advantage of selective COX-2 inhibitors is discussed in this chapter.Keywords: Antiinflammatory drugs, inflammation, antipyretic, analgesic, cyclooxygenase inhibitors, prostaglandin inhibitionTurkiye Klinikleri J Int Med Sci 2005, 1(9):24-34
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